I picked third, which this season is kind of a rough spot - the obvious first two players, Pujols and Santana, are just popular enough to really put you in an awkward situation, and I honestly think the 3-hole can be one of about 8 different players depending on your league parameters. This league used just about every category (including such ridiculous stuff as K/9 and using all of AVG, OBP, H and BB - Jesus), so that made for an interesting decision.
It's a head-to-head league - and here's a pro tip for you: in relatively deep head-to-head leagues, you can basically punt steals. Steals are generally overrated anyway, and unlike true Roto leagues, you only have to win more categories each week - it's hard to get buried, especially with 11 or more categories. Plus, steals are really a 'singular' category - guys with power add multi-dimensional aspects (HRs obviously lead to RBI, OPS and etc), but steals don't really correlate with anything else. However, this also means it's an easy category to win . . . my rule: don't pick steals-only guys, but look for a few guys who add 10 or 15 SB a year, and try to 'patch together' a few wins in the steals category. For a Roto league, throw this advice out the window.
For that reason, I punted on platinum hits like Reyes and Soriano, and went with Miguel Cabrera 3rd . . . BPro's Player Forecast Manager had him listed 4 (Ortiz was ahead), but I felt his all-around numbers and extremely positive health history pushed him ahead. Plus, he's basically mini-Pujols.
Another important point: 3B isn't really a difficult position to fill anymore . . . especially with guys like Alex Gordon going late, there's just no positional scarcity anymore. It's essentially equivalent to 1B now - however, 2B is rough, so I went Utley on the way back, then had to pick between Hafner and Sizemore next . . . I went Sizemore for overall numbers, but I'm not sure that's the right pick there.
Basically, so far my strategy has been to try to pick upper-echelon infielders early but recognize that SS and 3B can be filled on the cheap later - between Stephen Drew and others, you shouldn't need to sacrifice numbers on the alter of positional scarcity. Once the run on pitchers starts, I try to jump on the early end so I can fill for depth late, and unless you're getting BJ Ryan or Joe Nathan, don't waste a high pick on a reliever unless your league is way above average (if you have to think about it, it's not).
Don't expect to get Atkins that late, these kids are basically functionally retarded - also note that I may have overdrafted McCann, but the next pick was a total Braves homer and the drop-off after Mauer/McCann is kind of sick. Honestly, I think in a 10- or 12-team league I might even go as high as the 4th or 5th round, but he's pretty underrated by casual fans so try to let guys like him slide if you can.
MAKE MONEY MONEY MAKE MONEY MONEY MONEY